Extension of genetic analysis. Genes interaction. Advanced genetic analysis. Genetics of quantitative traits. Population genetics. Genetics of taste perception. Clock mutants and genetics of circadian rhythms. Genetics of aging. Developmental genetics. Bacterial genetics. Genetic editing.
Pierce, Genetica, seconda edizione, Zanichelli.
Russel P.J., Genetica, un approccio molecolare (4° edizione). Pearson.
Meneely P. Analisi genetica avanzata, McGraw-Hill.
Deho G. e Galli E., Biologia dei microrganismi, Casa editrice ambrosiana
On line additional material provided on the e-learning platform of the unifi website
Learning Objectives
Knowledge acquired:
Knowledge of advanced genetics of molecules, cells, organisms and populations. Genetic and genomic methods applied to the study of biological phenomena in the world of microbes, plants and animals, humans included.
Competence acquired
Principles of genetic analysis, extensions of Mendelian analysis. Quantitative genetics and applications. Population genetics and evolution of populations. Analysis of biological phenomena through genetic and genomic approaches.
Skills acquired (at the end of the course):
Use of techniques of genetic and genomic analysis. Application of genetic methods and genetic models to the understanding of biological issues. Use of mutants and genetic crosses in model organisms.
Prerequisites
Basic knowledge of genetics, molecular biology and microbiology
Teaching Methods
Lectures
Further information
Attending lessons highly recommended
Type of Assessment
Written examination
Course program
Extension of genetic analysis. Genes interaction, epistasis, suppression, enhancement. Advanced genetic analysis. Genetics of quantitative traits, polygenic traits, genetic and environmental variance, hereditability, artificial selection, mapping of polygenic loci, QTLs, twins. Population genetics, allelic and genotypic frequencies, hardy-Weinberg equilibrium, deviation from equilibrium, mutation, migration, genetic drift, inbreeding, natural selection, heterozygosity and polymorphism. Genetic of taste, the genes for taste receptors, evolution of taste receptors. Genetic of circadian rhythm, clock genes and mutants. Circadian rhythms in bacteria, plants and animals. Genetics of aging, model organisms for the study of aging, mutants altered in aging. Developmental genetics, sexual differentiation in Drosophila, development of Drosophila embryo. Bacterial genetics, genetics of cell cycle and differentiation. Genetic editing, the Crispr-Cas system and examples of application.