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B029428 - DRUG ANALYSIS II
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Sustainable Development Goals 2030
Academic Year 2022-23
Coorte 2019 - 5-years Single Cycle Degree in PHARMACY
Course year
Fourth year - Second Semester
Belonging Department
Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA)
Course Type
Single education field course
Scientific Area
CHIM/08 - PHARMACEUTICAL CHEMISTRY
Credits
9
Teaching Hours
90
Teaching Term
27/02/2023 ⇒ 16/06/2023
Attendance required
No
Type of Evaluation
Final Grade
Course Content
show
Course program
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Lectureship
- Last names A-L CROCETTI LETIZIA
- Last names A-L GUERRINI GABRIELLA
- Last names M-Z CROCETTI LETIZIA
- Last names M-Z DEI SILVIA
- Last names M-Z VERGELLI CLAUDIA
Teaching Language - Last names A-L
italian language
Teaching Language - Last names M-Z
Italian language
Course Content - Last names A-L
Identification of compounds registered in the FUI and in the EP.
Chemical and instrumental analysis of pharmaceutical structures and of some drug classes.
Chemical and instrumental analysis of pharmaceutical structures and of some drug classes.
Course Content - Last names M-Z
Identification of compounds registered in the FUI and in the EP.
Chemical and instrumental analysis of pharmaceutical structures and of some drug classes.
Chemical and instrumental analysis of pharmaceutical structures and of some drug classes.
Suggested readings - Last names A-L (Search our library's catalogue)
Slides are downloaded from Moodle (e-learning)
-Farmacopea Ufficiale italiana XII Ed.
-European Pharmacopoeia
-A. Carta, M. G. Mamolo , F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa - EDISES
-F. Savelli, O. Bruno, Analisi Chimico Farmaceutica - Piccin
-Cavrini, Andrisano, Analisi farmaceutica. Metodi di riconoscimento e di separazione - Esculapio
-Farmacopea Ufficiale italiana XII Ed.
-European Pharmacopoeia
-A. Carta, M. G. Mamolo , F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa - EDISES
-F. Savelli, O. Bruno, Analisi Chimico Farmaceutica - Piccin
-Cavrini, Andrisano, Analisi farmaceutica. Metodi di riconoscimento e di separazione - Esculapio
Suggested readings - Last names M-Z (Search our library's catalogue)
Slides are downloaded from Moodle (e-learning)
-Farmacopea Ufficiale italiana XII Ed.
-European Pharmacopoeia
-A. Carta, M. G. Mamolo , F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa - EDISES
-F. Savelli, O. Bruno, Analisi Chimico Farmaceutica - Piccin
-Cavrini, Andrisano, Analisi farmaceutica. Metodi di riconoscimento e di separazione - Esculapio
-Farmacopea Ufficiale italiana XII Ed.
-European Pharmacopoeia
-A. Carta, M. G. Mamolo , F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa - EDISES
-F. Savelli, O. Bruno, Analisi Chimico Farmaceutica - Piccin
-Cavrini, Andrisano, Analisi farmaceutica. Metodi di riconoscimento e di separazione - Esculapio
Learning Objectives - Last names A-L
The course is divided into theoretical lessons (36 hours, 4.5 credits) and practical exercises in a single place (54 hours, 4.5 credits).
The theoretical lessons aim to provide the student with the knowledge relating to the chemical and instrumental analysis methods for the identification and purity control of substances of pharmaceutical interest that will be necessary for carrying out the exercises.
Furthermore, the student will be able to consult the FUI and EP monographs consciously.
The theoretical lessons aim to provide the student with the knowledge relating to the chemical and instrumental analysis methods for the identification and purity control of substances of pharmaceutical interest that will be necessary for carrying out the exercises.
Furthermore, the student will be able to consult the FUI and EP monographs consciously.
Learning Objectives - Last names M-Z
The course is divided into theoretical lessons (36 hours, 4.5 credits) and practical exercitation in single place (54 hours, 4.5 credits).
The theoretical lessons aim to provide the student with the knowledge relating to the chemical and instrumental analysis methods for the identification and purity control of substances of pharmaceutical interest that will be necessary for carrying out the exercises.
Furthermore, the student will be able to consciously consult the FUI and EP monographs.
The theoretical lessons aim to provide the student with the knowledge relating to the chemical and instrumental analysis methods for the identification and purity control of substances of pharmaceutical interest that will be necessary for carrying out the exercises.
Furthermore, the student will be able to consciously consult the FUI and EP monographs.
Prerequisites - Last names A-L
Propaedeutic teachings are Drug Analysis I (part I and II). Basic knowledge of Organic Chemistry is also required.
Prerequisites - Last names M-Z
Propaedeutic teachings are Drug Analysis I (part I and II). Basic knowledge of Organic Chemistry is also required.
Teaching Methods - Last names A-L
Lectures supported by Power point presentation. Laboratory practice is carried out individually.
Didactic instruments: PC and video projector.
Didactic instruments: PC and video projector.
Teaching Methods - Last names M-Z
Lectures supported by Power point presentation. Laboratory practice is carried out individually.
Didactic instruments: PC and video projector.
Didactic instruments: PC and video projector.
Further information - Last names A-L
To make a date:
Dipartimento di NEUROFARBA, Sezione di Farmaceutica e Nutraceutica
Via U. Schiff, 6 - 50019 Sesto F.no - Firenze
Dott. Gabriella Guerrini
055 4573766
mail: gabriella.guerrini@unifi.it
Dipartimento di NEUROFARBA, Sezione di Farmaceutica e Nutraceutica
Via U. Schiff, 6 - 50019 Sesto F.no - Firenze
Dott. Gabriella Guerrini
055 4573766
mail: gabriella.guerrini@unifi.it
Further information - Last names M-Z
To make a date:
Dott. Vergelli: Tel 055 4573790, e-mail: claudia.vergelli@unifi.it
Dipartimento di NEUROFARBA,
Sezione di Farmaceutica e Nutraceutica
Via U. Schiff, 6 - 50019 Sesto F.no - Firenze
Dott. Vergelli: Tel 055 4573790, e-mail: claudia.vergelli@unifi.it
Dipartimento di NEUROFARBA,
Sezione di Farmaceutica e Nutraceutica
Via U. Schiff, 6 - 50019 Sesto F.no - Firenze
Type of Assessment - Last names A-L
There are 11 oral exam sessions per year, two of which in the didactic silence period, one per month excluding August. In addition, the June session may include an ‘extended session’ for those who attended the course in semester II of the current academic year.
In case of failure, students can enrol in the following useful exam session. Passing the Organic Chemistry and Medicinal Analysis I exams (modules I and II) is a requirement for the Medicines Analysis II exam.
Two evaluations will contribute to the final vote:
• The evaluation of the practical laboratory considers the individual work in the laboratory and the evaluation of the reports relating to the various ongoing tests and the final analysis.
The practice exercise include, infact, the unknown analysis of drugs reported in FUI XI. The student must accompany these analyses with a report in which he must document the logical path followed for recognising the substances through deductive processing of the data at his disposal. These reports will be corrected and evaluated.
• In the evaluation of the oral examination, whose about 50 minutes, the student is asked to write the formulas and reactions, solve spectroscopy exercises (IR and 1H-NMR) and, more generally, discuss the topics and concepts covered in class.
The final vote, will be refer to the evaluation grid on the website of CdS (Didattica-criteri attribuzione voti esami di profitto).
On the web page for the exam’s enrolment are reported the dates for the examination session.
In case of failure, students can enrol in the following useful exam session. Passing the Organic Chemistry and Medicinal Analysis I exams (modules I and II) is a requirement for the Medicines Analysis II exam.
Two evaluations will contribute to the final vote:
• The evaluation of the practical laboratory considers the individual work in the laboratory and the evaluation of the reports relating to the various ongoing tests and the final analysis.
The practice exercise include, infact, the unknown analysis of drugs reported in FUI XI. The student must accompany these analyses with a report in which he must document the logical path followed for recognising the substances through deductive processing of the data at his disposal. These reports will be corrected and evaluated.
• In the evaluation of the oral examination, whose about 50 minutes, the student is asked to write the formulas and reactions, solve spectroscopy exercises (IR and 1H-NMR) and, more generally, discuss the topics and concepts covered in class.
The final vote, will be refer to the evaluation grid on the website of CdS (Didattica-criteri attribuzione voti esami di profitto).
On the web page for the exam’s enrolment are reported the dates for the examination session.
Type of Assessment - Last names M-Z
There are 11 oral exam sessions per year, two of which in the didactic silence period, one per month excluding August. In addition, the June session may include an ‘extended session’ for those who attended the course in semester II of the current academic year.
In case of failure, students can enrol in the following useful exam session. Passing the Organic Chemistry and Medicinal Analysis I exams (modules I and II) is a requirement for the Medicines Analysis II exam.
Two evaluations will contribute to the final vote:
• The evaluation of the practical laboratory considers the individual work in the laboratory and and the evaluation of the reports relating to the various ongoing tests and the final analysis.
The practice exercise include, infact, the unknown analysis of drugs reported in FUI XI. The student must accompany these analyses with a report in which he must document the logical path followed for recognising the substances through deductive processing of the data at his disposal. These reports will be corrected and evaluated.
• In the evaluation of the oral examination, whose about 50 minutes, the student is asked to write the formulas and reactions, solve spectroscopy exercises (IR and 1H-NMR) and, more generally, discuss the topics and concepts covered in class.
The final vote, will be refer to the evaluation grid on the website of CdS (Didattica-criteri attribuzione voti esami di profitto).
On the web page for the exams enrolment are reported the dates for the examination session.
In case of failure, students can enrol in the following useful exam session. Passing the Organic Chemistry and Medicinal Analysis I exams (modules I and II) is a requirement for the Medicines Analysis II exam.
Two evaluations will contribute to the final vote:
• The evaluation of the practical laboratory considers the individual work in the laboratory and and the evaluation of the reports relating to the various ongoing tests and the final analysis.
The practice exercise include, infact, the unknown analysis of drugs reported in FUI XI. The student must accompany these analyses with a report in which he must document the logical path followed for recognising the substances through deductive processing of the data at his disposal. These reports will be corrected and evaluated.
• In the evaluation of the oral examination, whose about 50 minutes, the student is asked to write the formulas and reactions, solve spectroscopy exercises (IR and 1H-NMR) and, more generally, discuss the topics and concepts covered in class.
The final vote, will be refer to the evaluation grid on the website of CdS (Didattica-criteri attribuzione voti esami di profitto).
On the web page for the exams enrolment are reported the dates for the examination session.
Course program - Last names A-L
Safety regulations and first aid rules in chemical laboratory.
“Monograph” in European Pharmacopoiea and in Farmacopea Ufficiale Italiana
Preliminary tests: organoleptic examination, behavior to the heating (to distinguish organic substances from organometallic and inorganic substances), organic elemental analysis (Lassaigne test), metal analysis, physical properties determination, dissolution tests.
Salts analysis (organic and organometallic compounds).
Chemical Analysis for the characterization of olefin and phenyl groups, hydroxyl function (alcohol, phenol), carbonyl function (aldehyde, ketone), carboxyl function (carboxyl acid and functional derivatives), aminic function (primary, secondary, tertiary, aliphatic and aromatic amines), sulfonamides, nitroderivatives.
Analysis of pharmaceutical structures and of some drug classes FUI and EP: Acetates, Alkaloids, Amino Acids, Barbiturates, Benzoates, Carbohydrates, Citrates, Lactates, Phenols, Polyalcohol derivatives, Pyrazolone derivatives, Pyridine and Pyrimidine derivatives, Salicylates, Sulfonamides, Tartrates, Xanthine.
Basic knowledge and applications of instrumental technologies for the characterization of pharmaceuticals: IR spectroscopy. An outline of the 1H-NMR and MS.
Explanation of the Tables, utilized in laboratory, for identification of unknown compounds.
Systematic procedure to identification of pharmaceuticals registered in the European Pharmacopoeia IX.
“Monograph” in European Pharmacopoiea and in Farmacopea Ufficiale Italiana
Preliminary tests: organoleptic examination, behavior to the heating (to distinguish organic substances from organometallic and inorganic substances), organic elemental analysis (Lassaigne test), metal analysis, physical properties determination, dissolution tests.
Salts analysis (organic and organometallic compounds).
Chemical Analysis for the characterization of olefin and phenyl groups, hydroxyl function (alcohol, phenol), carbonyl function (aldehyde, ketone), carboxyl function (carboxyl acid and functional derivatives), aminic function (primary, secondary, tertiary, aliphatic and aromatic amines), sulfonamides, nitroderivatives.
Analysis of pharmaceutical structures and of some drug classes FUI and EP: Acetates, Alkaloids, Amino Acids, Barbiturates, Benzoates, Carbohydrates, Citrates, Lactates, Phenols, Polyalcohol derivatives, Pyrazolone derivatives, Pyridine and Pyrimidine derivatives, Salicylates, Sulfonamides, Tartrates, Xanthine.
Basic knowledge and applications of instrumental technologies for the characterization of pharmaceuticals: IR spectroscopy. An outline of the 1H-NMR and MS.
Explanation of the Tables, utilized in laboratory, for identification of unknown compounds.
Systematic procedure to identification of pharmaceuticals registered in the European Pharmacopoeia IX.
Course program - Last names M-Z
Safety regulations and first aid rules in chemical laboratory.
“Monograph” in European Pharmacopoiea and in Farmacopea Ufficiale Italiana
Preliminary tests: organoleptic examination, behavior to the heating (to distinguish organic substances from organometallic and inorganic substances), organic elemental analysis (Lassaigne test), metal analysis, physical properties determination, dissolution tests.
Salts analysis (organic and organometallic compounds).
Chemical Analysis for the characterization of olefin and phenyl groups, hydroxyl function (alcohol, phenol), carbonyl function (aldehyde, ketone), carboxyl function (carboxyl acid and functional derivatives), aminic function (primary, secondary, tertiary, aliphatic and aromatic amines), sulfonamides, nitroderivatives.
Analysis of pharmaceutical structures and of some drug classes FUI and EP: Acetates, Alkaloids, Amino Acids, Barbiturates, Benzoates, Carbohydrates, Citrates, Lactates, Phenols, Polyalcohol derivatives, Pyrazolone derivatives, Pyridine and Pyrimidine derivatives, Salicylates, Sulfonamides, Tartrates, Xanthine.
Basic knowledge and applications of instrumental technologies for the characterization of pharmaceuticals: IR spectroscopy. An outline of the 1H-NMR and MS.
Explanation of the Tables, utilized in laboratory, for identification of unknown compounds.
Systematic procedure to identification of pharmaceuticals registered in the European Pharmacopoeia VII.
“Monograph” in European Pharmacopoiea and in Farmacopea Ufficiale Italiana
Preliminary tests: organoleptic examination, behavior to the heating (to distinguish organic substances from organometallic and inorganic substances), organic elemental analysis (Lassaigne test), metal analysis, physical properties determination, dissolution tests.
Salts analysis (organic and organometallic compounds).
Chemical Analysis for the characterization of olefin and phenyl groups, hydroxyl function (alcohol, phenol), carbonyl function (aldehyde, ketone), carboxyl function (carboxyl acid and functional derivatives), aminic function (primary, secondary, tertiary, aliphatic and aromatic amines), sulfonamides, nitroderivatives.
Analysis of pharmaceutical structures and of some drug classes FUI and EP: Acetates, Alkaloids, Amino Acids, Barbiturates, Benzoates, Carbohydrates, Citrates, Lactates, Phenols, Polyalcohol derivatives, Pyrazolone derivatives, Pyridine and Pyrimidine derivatives, Salicylates, Sulfonamides, Tartrates, Xanthine.
Basic knowledge and applications of instrumental technologies for the characterization of pharmaceuticals: IR spectroscopy. An outline of the 1H-NMR and MS.
Explanation of the Tables, utilized in laboratory, for identification of unknown compounds.
Systematic procedure to identification of pharmaceuticals registered in the European Pharmacopoeia VII.