Classification; morphological and behavioral characteristics of the neoplastic cell; epidemiology of tumors; genetic and non-genetic factors; molecular basis of cancer; oncogenes and tumor suppressors; tumor angiogenesis; genomic instability and tumor progression; local invasion and metastasis; chemical, physical and biological carcinogenesis; immunity and tumors; clinical classification.
Patologia generale e fisiopatologia generale
Pontieri - Mainiero - Misasi - Sorice - AAVV - 2018
Patologia generale - Robbins e Cotran: Le basi patologiche delle malattie
Abul K. Abbas, N Fausto, Vinay Kumar, Jon C. Aster - 2010
All the presentations will be available on the Moodle page of the course
Oncologia generale
Tolone - 2008
Learning Objectives
The objective of the course is to provide an integral view of oncology, from its biological basis to clinical consequences, from morphological characterization to surgical, radiotherapy and medical treatments.
Acquired skills:
definition of the characteristics of the neoplastic cell; knowledge of the most common types of cancer and their classification; molecular markers used for diagnostics and clinics. Evaluation of tumor histological preparations.
Prerequisites
Recommended courses: Cytology and histology, Biochemistry.
Teaching Methods
Frontal lessons
Seminars
Exercises with virtual microscope or similar platforms
Type of Assessment
1. Evaluation of tumour histological slides
2. Written test with open questions and multiple answers questions
3. Oral exam
Course program
Tumors: definition and characteristics of neoplastic development
Classification and nomenclature
Staging of tumors
Biology of tumor growth
Biological characteristics of neoplastic cells
Diagnostic methods: cytology and histology
Epidemiology
Risk factors
Histopathology
Chemical carcinogenesis
Physical carcinogenesis
Viral carcinogenesis
Hormonal carcinogenesis
Molecular oncology:
Oncogenes
tumor suppressor genes
Oncogenes and tumor suppressors in therapy
Epigenetics
Tumor progression and heterogeneity
Genetic evolution of tumors
Angiogenesis and Metastatization
Molecular aspects of cancer diagnostics
Clinical features of tumors:
Cancer stem cells
Local and hormonal effects
Neoplastic cachexia
Paraneoplastic syndromes
Immunity and tumors
Principles of antineoplastic therapy
Tumor markers