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B028064 - MOLECULAR BIOLOGY AND EPIGENETICS
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2019-20
Coorte 2019 - Second Cycle Degree in MOLECULAR AND APPLIED BIOLOGY
Course year
First year - Second Semester
Belonging Department
Biology (BIO)
Course Type
Single education field course
Scientific Area
BIO/11 - MOLECULAR BIOLOGY
Credits
9
Teaching Hours
72
Teaching Term
24/02/2020 ⇒ 12/06/2020
Attendance required
No
Type of Evaluation
Final Grade
Course Content
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Course program
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Lectureship
Teaching Language
Italian
Course Content
Control of Gene Expression in eukaryotes, Factors involved in the regulation of gene transcription. factors involved in Chromatin remodelling. Epigenetic factors. Gene silencing and micro RNA. Organism and cellular models. Cell- Cycle and regulatory factors of cell proliferation and cell arrest. Apoptosis. Differentiated Cells and the Maintenance of Tissue. Cytoskeleton structure and remodelling. Cell Junctions, Cell Adhesion and Cell motility and the Extracellular Matrix. Microenviroment
Suggested readings (Search our library's catalogue)
Alberts et al." Biologia Molecolare della cellula" Ed. Zanichelli
Darnell, Lodish: Biologia molecolare della cellula Ed. Zanichelli
T.A. Brown "Genomi" Ed. Edises
Lewin Benjamin; Il gene VIII; Ed. Zanichelli
R.F. Gesteland and J.F. Atkins, The RNA World -
J. Watson,Biologia Molecolare del Gene . Ed. Zanichelli
Darnell, Lodish: Biologia molecolare della cellula Ed. Zanichelli
T.A. Brown "Genomi" Ed. Edises
Lewin Benjamin; Il gene VIII; Ed. Zanichelli
R.F. Gesteland and J.F. Atkins, The RNA World -
J. Watson,Biologia Molecolare del Gene . Ed. Zanichelli
Learning Objectives
Knolewdge acquired:
Regulation of gene expression in eukaryotes and techniques for gene expression evaluation. Molecular aspects of the principal biological processes: cell growth, differentiation, cell death and motility and specific techniques for their evaluation
Competence acquired
Terminology. Basic aspects and molecular factors involved in the control of the fundamental biological processes: cell growth, differentiation, death, motility and adhesion.
Molecular factors of the signalling pathways leading to cell survive and death.
Skills acquired (at the end of the course):
To identify the appropriate tecniques for evaluating gene expression, cell proliferation, death, differentiation, motility in the eukaryotes
To develop skills for critical analyses and synthesis of acquired information.To acquire abilities for communication of scientific information.
Regulation of gene expression in eukaryotes and techniques for gene expression evaluation. Molecular aspects of the principal biological processes: cell growth, differentiation, cell death and motility and specific techniques for their evaluation
Competence acquired
Terminology. Basic aspects and molecular factors involved in the control of the fundamental biological processes: cell growth, differentiation, death, motility and adhesion.
Molecular factors of the signalling pathways leading to cell survive and death.
Skills acquired (at the end of the course):
To identify the appropriate tecniques for evaluating gene expression, cell proliferation, death, differentiation, motility in the eukaryotes
To develop skills for critical analyses and synthesis of acquired information.To acquire abilities for communication of scientific information.
Prerequisites
Courses recommended: Biochemistry, Genetics
Teaching Methods
.
Further information
.
Type of Assessment
Oral exam
Course program
Regulation of gene expression in eukaryotes. Structure and regulation of transcription factors: Chromatin remodelling (Swi/sfn complex, HMG proteins). Transient, semipermanent and permanent gene expression. Cell specification and differentiation.Epigenetic factors. Gene silencing and microRNA. Molecular aspects of the principal biological processes: cell growth, differentiation, cell death and motility. Stem cells and tissue regeneration. Adesion molecules and cell adhesion; Extracellular matrix remodelling. Cytoskeleton: structure and function. Cell communication: gap junctions Methodologies for the evaluation of cell growth, cell death and cell migration.