B029324 - THE ROOTS OF CANCER: A GENERAL OVERVIEW OF THE CURRENT MULTIPLE MODELS AT THE MOLECULAR BIOLOGICAL MODELS

Italian

Role of different oncogenes and oncosuppressor in cancer. Molecular mechanisms of oncogene activation and oncosuppressor disactivation.

Robert Weinberg - Molecular biology of cancer - Zanichelli

Give the elements to understand, at a molecular level, the role of oncogenes and oncosuppressors in tumor progression.

Knowing the contents of the first year courses.

Seminars

written test

Definition of oncogene. Historical experiments and modern methods of oncogene characterization. Different way of oncogene activation: mutation in the coding sequence, gene translocation, gene amplification. Description of the different mechanisms of activation for several oncogenes. Definition of an oncosuppressor gene and mechanism of inactivation: direct inactivation, LOH, promoter hypermethylation