The first part of the course is devoted to the fundamentals of spectroscopy, including interpretation and applications of molecular spectroscopy to biochemical systems. Concepts and principles of electronic absorption and emission, circular dichroism, vibrational spectroscopy (IR, FTIR, Raman and resonance Raman) are given. The second part is devoted to thermodynamics. The main topics include chemical themodynamics and equilibria, change of state, kinetic theory and chemical kinetics.
P. Atkins, J. De Paula "Chimica Fisica" Zanichelli, seventh edition.
P. Atkins, J. De Paula, Physical Chemistry
Oxford, eight edition
Donald A. McQuarrie, John D. Simon "Chimica Fisica, un approccio molecolare" Ed. Zanichelli
Walter J. Moore "Chimica Fisica" Piccin
Cantor and Schimmel "Biophysical Chemistry. Part II: Techniques for the study of biological structure and function" W.H. Freeman and Co, San Francisco.
Jeanne L. McHale "Molecular Spectroscopy" Prentice Hall, New Jersey
Gordon M. Barrow "Physical Chemistry" Sixth Edition, WCB, McGraw-Hill
Learning Objectives
Provide basic information on the modern Molecular Spectroscopy and the application on biological molecules and drugs.
Provide the fundamentals concepts of thermodynamics, (Enthalpy, Entropy, Gibbs Energy), Thermochemistry, Kinetics, Physical Transformation.
Lessons of theory and training consisting of the solution of numerical excercices.
Lessons of theory will be held by using board and supported through the projection of slides whixch are provided to the students in pdf format.
In the practice sessions numerical exercises will be solved in several manners: together with the teacher, in small groups of 2-4 students and individually.
Optional practice will be offer for the solution of numerical exercices.
Further information
Via della Lastruccia, 3 - 50019 Sesto Fiorentino
Tel. 055 4573083
E_mail: giulietta.smulevichunifi.it
Type of Assessment
There are three written tests in progress during the course on: 1) Principles of spectroscopy and symmetry; Electronic spectroscopies: UV-Vis, Fluorescence, phosphorescence, CD; 2) Vibrational spectroscopies: IR, FTIR, Raman, resonant Raman, microRaman; principles of structural chemistry: X-ray diffraction; 3) Thermochemistry, phase equilibria, kinetics.
The ongoing tests are valid until the February appeal of the current academic Year. For those students who have passed the tests in progress and have passed Physics, General and inorganic Chemistry, and Computational Chemistry, the final exam consists of an about 20 minutes oral exam on a topic chosen by the teacher. For students who have not passed the tests during the course, the final oral examination will cover the whole program of the course and the student will be called to describe and apply the topics and concepts covered in class.
There are 5 official appeals in the summer session June-September, 2 calls in the winter session January-February. In addition, there are 2 calls, one in December and one in April, during periods of educational silence.
Course program
Molecular Spectroscopy. Principles of symmetry. UV-Vis, Fluorescence, Phosphorescence, Circular Dichroism, IR, FTIR, Raman, Resonance Raman, MicroRaman, X-Ray diffraction. Application to biological systems.
Themochemistry, Physical Transformations, Phase Diagrams, Chemical Equilibrium, kinetics, Molecular reaction dynamics.